Case-control study and meta-analysis of Ser311Cys polymorphism in the DRD2 gene demonstrate lack of association with risk for schizophrenia in the Japanese population
نویسندگان
چکیده
1Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan 2Division of Medical Education, Comprehensive Medical Education Center, School of Medicine, Faculty of Medicine, Niigata University, Niigata, Japan 3Niigata Psychiatric Center, Nagaoka, Niigata, Japan 4Ohjima Hospital, Sanjo, Niigata, Japan 5Health Administration Center, Headquarters for Health Administration, Niigata University, Niigata, Japan 6Department of Psychiatry, National Hospital Organization, Saigata National Hospital, Joetsu, Niigata, Japan
منابع مشابه
Study of the association between DRD2 Gene Ser311Cys and GSTM1 Gene polymorphism in Schizophrenia
Introduction: Schizophrenia is a mental disorder affecting 1% of the world's population. Two of genes have been recognized to be involved in development of this disease: DRD2 and GSTM1. Methods: This case-control study included 100 patients suffering from schizophrenia who referred to Yazd Neuropsychiatry Hospital. Also, 100 healthy patients without schizophrenia were selected as the control g...
متن کاملAssociation between Ser311Cys polymorphism in the dopamine D2 receptor gene and schizophrenia risk: a meta-analysis in Asian populations.
Numerous studies have evaluated the association between Ser311Cys (rs1801028, C>G) polymorphism of the dopamine D2 receptor (DRD2) gene and schizophrenia risk. However, the specific association is still controversial. We examined whether DRD2 Ser311Cys polymorphism confers schizophrenia risk in Asian populations. Sixteen studies were retrieved reporting on a total of 2268 schizophrenia pa...
متن کاملHyperprolactinemia and CYP2D6, DRD2 and HTR2C genes polymorphism in patients with schizophrenia
Introduction: Hyperprolactinemia is a common serious side effect of antipsychotic medications that are currently used in the treatment of patients with schizophrenia. Pharmacogenetic approaches offer the possibility of identifying patient-specific biomarkers for predicting the risk of this side effect. We investigated a possible relationship between variants (SNPs) in genes for cytochrome 2D6 (...
متن کاملThe Association of DRD2 Gene TaqI Polymorphism with Attention Deficit Hyperactivity Disorder a Population Sample of Iranian Azeri-children
Background Attention deficit hyperactivity disorder (ADHD) is a multi-factorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotide polymorphisms in DRD2 gene, Taq I A (T/C) and Taq I B (G/A), with ADH...
متن کاملStudy of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri
BackgroundAttention deficit hyperactivity disorder (ADHD), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. The aim of this study was to examine the association of -141 polymorphisms in DRD2 gene with ADHA among Iranian-Azeri population.Materials and Methods A case–control association study included 153 patients with attention defi...
متن کامل